Selected publications
^: co-first authors, * corresponding authors
20. Development of an MHC imputation panel highlights independent contributions of HLA amino acid residues and C4 copy number variations to SLE risk
Chae-Yeon Yu^, Dong Mun Shin^, Sung Min Kim, Yui Taek Lee, Sungwon Jeon, Sehwan Chun, So-Young Bang, Hye-Soon Lee, Xianyong Yin, Yong Cui, Xuejun Zhang, Jong Bhak, Soon Ji Yoo, Young Jin Kim*, Bong-Jo Kim*, Sang-Cheol Bae*, Kwangwoo Kim*.
Annals of the Rheumatic Diseases. in press. doi: 10.1016/j.ard.2025.06.2121. [July, 2025] [IF=20.6]
19. Genetic burden of lupus increases the risk of transition from normal to preclinical autoimmune conditions via antinuclear antibody development
Sehwan Chun^, So-Young Bang^, Ayeong Kwon, Chan Young Kim, Soojin Cha, Young-Chang Kwon, Young Bin Joo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Ji-Young Han, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Hye-Soon Lee, Kwangwoo Kim*, Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 84(5):789-797. doi: 10.1016/j.ard.2025.01.015. [May, 2025] [IF=20.6]
18. Higher genetic risk loads confer more diverse manifestations and higher risk of lupus nephritis in systemic lupus erythematosus
Young-Chang Kwon^, Eunji Ha^, Hyuk-Hee Kwon, Dae Jin Park, Jung-Min Shin, Young Bin Joo, Won Tae Chung, Dae-Hyun Yoo, Hye-Soon Lee, Kwangwoo Kim*, Sang-Cheol Bae*, So-Young Bang*.
Arthritis & Rheumatology. 75(9):1566-1572. doi: 10.1002/art.42516. [September 2023] [IF=10.9]
17. Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study
Xianyong Yin^, Kwangwoo Kim^, Hiroyuki Suetsugu^, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yong-Fei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Yu Lung Lau, Ken Yamaji, Zhengwei Zhu, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head; Kazuhiko Yamamoto, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao*, Yong Cui*, Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 81(9):1273-1280. doi: 10.1136/annrheumdis-2022-222345. [August 2022] [IF=20.6]
16. Recent advances in understanding the genetic basis of systemic lupus erythematosus
Eunji Ha, Sang-Cheol Bae*, Kwangwoo Kim*.
Seminars in Immunopathology. 44(1):29-46. doi: 10.1007/s00281-021-00900-w. [January 2022] [IF=9.2]
15. Genetic variants shape rheumatoid arthritis-specific transcriptomic features in CD4+ T cells through differential DNA methylation, explaining a substantial proportion of heritability
Eunji Ha^, So-Young Bang^, Jiwoo Lim, Jun Ho Yun, Jeong-Min Kim, Jae-Bum Bae, Hye-Soon Lee, Bong-Jo Kim*, Kwangwoo Kim*, Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 80(7):876-883. doi: 10.1136/annrheumdis-2020-219152. [July 2021] [IF=20.6]
[resource] DEG/DMR/QTL summary statistics: https://doi.org/10.5061/dryad.w0vt4b8pw
14. Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci
Eunji Ha, Sang-Cheol Bae*, Kwangwoo Kim*.
Annals of the Rheumatic Diseases, 80(5):558-565. doi: 10.1136/annrheumdis-2020-219065. [May 2021] [IF=20.6]
[featured] Nature Reviews Rheumatology (Feb 8, 2021; https://www.nature.com/articles/s41584-021-00580-8).
[resource] Association summary statistics: https://doi.org/10.5061/dryad.ns1rn8pr0.
13. Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus
Xianyong Yin^, Kwangwoo Kim^, Hiroyuki Suetsugu^, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Viktoryia Laurynenka, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yongfei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Ken Yamaji, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head, Leah C. Kottyan, Matthew T. Weirauch, Sreeja Parameswaran, Shruti Eswar, Hanan Salim, Xiaoting Chen, Kazuhiko Yamamoto, John B. Harley, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao*, Yong Cui*, Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 80(5):632-640. doi: 10.1136/annrheumdis-2020-219209. [May 2021] [IF=20.6]
12. Allele-specific quantification of HLA-DRB1 transcripts reveals imbalanced allelic expression that modifies the amino acid effects in HLA-DRβ1
Sehwan Chun^, So-Young Bang^, Eunji Ha, Jing Cui, Ki-Nam Gu, Hye-Soon Lee, Kwangwoo Kim*, Sang-Cheol Bae*. Arthritis & Rheumatology. 73(3):381-391. doi: 10.1002/art.41535. [March 2021] [IF=10.9]
11. Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis
Young-Chang Kwon^, Jiwoo Lim^, So-Young Bang^, Eunji Ha, Mi Yeong Hwang, Kyungheon Yoon, Jung-Yoon Choe, Dae-Hyun Yoo, Shin-Seok Lee, Jisoo Lee, Won Tae Chung, Tae-Hwan Kim, Yoon-Kyoung Sung, Seung-Cheol Shim, Chan-Bum Choi, Jae-Bum Jun, Young Mo Kang, Jung-Min Shin, Yeon-Kyung Lee, Soo-Kyung Cho, Bong-Jo Kim, Hye-Soon Lee, Kwangwoo Kim*, Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 79(11):1438-1445. doi: 10.1136/annrheumdis-2020-217663. [November 2020] [IF=20.6]
10. Massive false positive gene-gene interactions by Rothman’s additive model
Kwangwoo Kim*.
Annals of the Rheumatic Diseases. 78(3):437-439. doi: 10.1136/annrheumdis-2018-214297. [March 2019] [IF=20.6]
9. Update on the genetic architecture of rheumatoid arthritis
Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, and Sang-Cheol Bae*.
Nature Reviews Rheumatology. 13(1):13-24. doi: 10.1038/nrrheum.2016.176. [January 2017] [IF=32.7]
8. Identification of a systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2, and P2RY2 in Koreans
Christopher J. Lessard^, Satria Sajuthi^, Jian Zhao^, Kwangwoo Kim^, John A. Ice, He Li, Hannah Ainsworth, Astrid Rasmussen, Jennifer A. Kelly, Mindy Marion, So-Young Bang, Young Bin Joo, Jeongim Choi, Hye-Soon Lee, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Soo-Kon Lee, Jung-Yoon Choe, Seung Cheol Shim, Ji Hee Oh, Young Jin Kim, BokGhee Han, Nan Shen, Hwee Siew Howe, Edward K. Wakeland, QuanZhen Li, Yeong Wook Song, Patrick M. Gaffney, Marta E. Alarcón-Riquelme, Lindsey A. Criswell, Chaim O. Jacob, Robert P. Kimberly, Timothy J. Vyse, John B. Harley, Kathy L. Sivils, Sang-Cheol Bae*, Carl D. Langefeld, and Betty P. Tsao*.
Arthritis & Rheumatology. 68(5):1197-209. doi: 10.1002/art.39548. [May 2016] [IF=10.9]
7. High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Celi Sun^, Julio E. Molineros^, Loren L. Looger^, Xu-jie Zhou^, Kwangwoo Kim^, Yukinori Okada, Jianyang Ma, Yuan-yuan Qi, Xana Kim-Howard, Prasenjeet Motghare, Krishna Bhattarai, Adam Adler, So-Young Bang, Hye-Soon Lee, Tae-Hwan Kim, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Yong-Beom Park, Jung-Yoon Choe, Seung Cheol Shim, Yuta Kochi, Akari Suzuki, Michiaki Kubo, Takayuki Sumida, Kazuhiko Yamamoto, Shin-Seok Lee, Young Jin Kim, Bok-Ghee Han, Mikhail Dozmorov, Kenneth M. Kaufman, Jonathan D. Wren, John B. Harley, Nan Shen, Kek Heng Chua, Hong Zhang, Sang-Cheol Bae*, and Swapan K. Nath*.
Nature Genetics. 48(3):323-30. doi: 10.1038/ng.3496. [March 2016] [IF=29.0]
[resource] Association summary statistics: Supplementary Data Set
6. Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis
Kwangwoo Kim^, Xia Jiang^, Jing Cui^, Bing Lu, Karen H. Costenbader, Jeffrey A. Sparks, So-Young Bang, Hye-soon Lee, Yukinori Okada, Soumya Raychaudhuri, Lars Alfredsson, Sang-Cheol Bae*, Lars Klareskog*, and Elizabeth W. Karlson*.
Arthritis & Rheumatology. 67(10):2611-23. doi: 10.1002/art.39228. [October 2015] [IF=10.9]
[featured] in the issue.
5. High-Density Genotyping of Immune Loci in Koreans and Europeans Identifies 8 New Rheumatoid Arthritis Risk Loci
Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Young Mo Kang, Seong-Kyu Kim, Chang-Hee Suh, Seung-Cheol Shim, Shin-Seok Lee, Jisoo Lee, Won Tae Chung, Jung-Yoon Choe, Hyoung Doo Shin, Jong-Young Lee, Bok-Ghee Han, Swapan K. Nath, Steve Eyre, John Bowes, Dimitrios A. Pappas, Joel M. Kremer, Miguel A Gonzalez-Gay, Luis Rodriguez-Rodriguez, Lisbeth Ärlestig, Yukinori Okada, Dorothée Diogo, Katherine P. Liao, Elizabeth W. Karlson, Soumya Raychaudhuri, Solbritt Rantapää-Dahlqvist, Javier Martin, Lars Klareskog, Leonid Padyukov, Peter K. Gregersen, Jane Worthington, Jeffrey D. Greenberg, Robert M. Plenge*, and Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 74(3):e13. doi: 10.1136/annrheumdis-2013-204749. [May 2015] [IF=20.6]
4. The HLA-DRβ1 Amino Acid Positions 11-13-26 Explain the Majority of SLE-MHC Associations
Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Yukinori Okada, Buhm Han, Woei-Yuh Saw, Yik-Ying Teo, and Sang-Cheol Bae*.
Nature Communications, 5:5902. doi: 10.1038/ncomms6902. [December 2014] [IF=15.7]
3. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries
Kwangwoo Kim^, Elizabeth E. Brown^, Chan-Bum Choi, Marta E. Alarcón-Riquelme on behalf of BIOLUPUS, Jennifer A. Kelly, Stuart B. Glenn, Joshua O. Ojwang, Adam Adler, Hye-Soon Lee, Susan A. Boackle, Lindsey A. Criswell, Graciela S. Alarcón, Jeffrey C. Edberg, Anne M. Stevens, Chaim O. Jacob, Gary S. Gilkeson, Diane L. Kamen, Betty P. Tsao, Juan-Manuel Anaya, Joel M. Guthridge, Swapan K. Nath, Bruce Richardson, Amr H. Sawalha, Young Mo Kang, Seung Cheol Shim, Chang-Hee Suh, Soo-Kon Lee, Chang-sik Kim, Joan T. Merrill, Michelle Petri, Rosalind Ramsey-Goldman, Luis M. Vilá, Timothy B. Niewold, Javier Martin, Bernardo A. Pons-Estel on behalf of GENLES, Timothy J. Vyse, Barry I. Freedman, Kathy L. Moser, Patrick M. Gaffney, Adrienne Williams, Mary Comeau, John D. Reveille, Judith A. James, R. Hal Scofield, Carl D. Langefeld, Kenneth M. Kaufman, John B. Harley, Changwon Kang*, Robert P. Kimberly*, and Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 71 (11), 1809-1814. doi: 10.1136/annrheumdis-2011-201110. [October 2012]. [IF=20.6]
[featured] as "Editor's Choice"
2. Replicated Association of a Regulatory Polymorphism in the Interferon-gamma Gene with Lupus Susceptibility
Kwangwoo Kim^, So-Yeon Park^, Taehyeung Kim, Young Mo Kang, Seung-Cheol Shim, Chang-Hee Suh, Yong-Beom Park, Chang-sik Kim, Changwon Kang*, and Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 70 (10) 1878-1879. doi: 10.1136/ard.2010.147249. [October 2011] [IF=20.6]
1. Interferon-gamma Gene Polymorphisms Associated with Susceptibility to Systemic Lupus Erythematosus
Kwangwoo Kim^, Soo-Kyung Cho^, Andrea Sestak, Bahram Namjou, Changwon Kang*, and Sang-Cheol Bae*.
Annals of the Rheumatic Diseases. 69 (6),1247-1250. doi: 10.1136/ard.2009.117572. [June 2010]. [IF=20.6]
*Award of the Best 100 Basic Research Achievements and the Best 100 National R&D Achievements from MoEST on Feb 2011.